Current Trials



ALLEGRO: A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery

ASICA: Achieving self-directed integrated Cancer Aftercare

Bridge-it: A randomised controlled trial to determine the effectiveness of bridging from emergency to regulary contraception

C-GALL: A randomised controlled trial comparing the clinical effectiveness and cost-effectiveness of laparoscopic cholecystectomy compared with observation/conservative management for preventing recurrent symptoms and complications in adults with uncomplicated symptomatic gallstones

CLaSS: Comparison of LAser, Surgery and foam Sclerotherapy

CSAW: Can Shoulder Arthroscopy Work? Is arthroscopic sub-acromial decompression (ASAD) more effective than arthroscopy only for shoulder pain?

DyNAMISM: Do Non-steroidal Anti-inflammatory drugs (NSAIDs) reduce the appearance of sacroiliac joint bone marrow oedema on MRI, in spondyloarthritis?

EDNA: Early Detection of Neovascular Age-related macular degeneration

ELECTRIC: ELECtric Tibial nerve stimulation to Reduce Incontinence in Care homes

EMPOWER: Early signs monitoring to prevent relapse and promote wellbeing, engagement and recovery

FOCUS: Focusing On Clozapine Unresponsive Symptoms

FUTURE: Female Urgency, Trial of Urodynamics as Routine Evaluation; a superiority randomised clinical trial to evaluate the effectiveness and cost effectiveness of invasive urodynamic investigations in management of women with refractory overactive bladder symptoms

GAPS: Graduated compression as an Adjunct to Pharmacoprophylaxis in Surgery

GOT-IT: A pragmatic group sequential placebo controlled randomised trial to determine the effectiveness of Glyceryl trinitrate for retained placenta

HEALTH: Hysterectomy or Endometrial AbLation Trial for Heavy menstrual bleeding:  A multicentre randomised controlled trial comparing laparoscopic supra-cervical hysterectomy with second generation endometrial ablation for the treatment of heavy menstrual bleeding

Interval: Investigation of NICE technologies for Enabling Risk-Variable-Adjusted-Length Dental Recall Trial

IQuaD: Improving the Quality of Dentistry: A randomised controlled trial comparing oral hygiene advice and periodontal instrumentation for the prevention and management of periodontal disease in dentate adults attending dental primary care

KAT: Knee Arthroplasty Trial

LIFT: Lessening the Impact of Fatigue in inflammatory rheumatic diseases: a randomised clinical trial

Liverhope: Safety & tolerability of the combination of simvastatin plus rifaximin in patients with decompensated cirrhosis: a multicenter, double-bling, placebo controlled randomised clinical trial (Liverhope Safety)

MAmMOTH:The Maintaining Musculoskeletal Health Study

MASTER: Male synthetic sling versus Artificial urinary Sphincter for men with urodynamic stress incontinence after prostate surgery: Evaluation by Randomised controlled trial

OPEN: Clarifying the management of men with recurrent urethral stricture - A pragmatic, randomised, multicentre superiority trial of open urethroplasty versus endoscopic urethrotomy

OPAL: Optimising Pelvic floor exercises to Achieve Longterm benefits.  Multicentre randomised trial of the effectiveness and cost-effectiveness of basic versus biofeedback-mediated intensive pelvic floor muscle training for female stress or mixed urinary incontinence

PHOTO: PHOTOdynamic versus white light-guided treatment of non-muscle invasive bladder cancer: A randomised trial of clinical and cost-effectiveness

PROSPECT: PROlapse Surgery: Pragmatic Evaluation and randomised Controlled Trial

PUrE: The clinical and cost effectiveness of surgical interventions for stones in the lower calyx of the kidney: The PUrE RCT- Percutaneous Nephrolithotomy (PNL), Flexible Ureterorenoscopy (FURS) and Extracorporeal Lithotripsy (ESWL) for lower pole Calyceal Kidney Stones

QUIDS: Quantitative Fibronectin to help Decision-making in women with Symptoms of Preterm Labour

RAACENO: Reducing Asthma Attacks in Children using Exhaled Nitric Oxide as a biomarker to inform treatment strategy - a randomised trial

REFLECT: A Randomised controlled trial to Evaluate the effectiveness and cost benefit of prescribing high dose fluoride toothpaste in preventing and treating dental Caries in high-risk older adulTs

SIMS: Single-incision adjustable mini-slings versus standard tension-free mid-urethral slings in the management of stress urinary incontinence: a pragmatic multicentre non-inferiority randomised controlled trial

STOPPIT-2: An open randomised trial of the Arabin pessary to prevent preterm birth in twin pregnancy, with health economics and acceptability

TAGS: Treatment of Advanced Glaucoma Study.  A multicentre randomised controlled trial comparing primary medical treatment with primary trabeculectomy for people with newly diagnosed advanced glaucoma

THISTLE: Improving intrapartum outcomes for mothers and babies in Scotland: a stepped-wedge RCT of an intrapartum emergencies training package in 15 Scottish maternity units

TISU: Therapeutic Interventions for Stones of the Ureter

TOPKAT: Total or Partial Knee Arthroplasty Trial

TOPSY: A multicentre randomised controlled trial, with nested process evaluation, to test the clinical and cost-effectiveness of self-management of vaginal pessaries to treat pelvic organ prolapse, compared to standard care to improve women's quality of life

TRUCK:Explanatory comparative study of conventional Total Knee Arthroplasty versus Robotic assisted Bi-UniCompartmental Knee Arthroplasty

TWICS: Theophylline with inhaled corticosteroids

UK REBOA: A randomised controlled trial of the effectiveness, and cost-effectiveness, of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) for trauma

UK TAVI: The United Kingdom Transcatheter Aortic Valve Implantation Trial

VUE: Vault or Uterine prolapse surgery Evaluation