Dr Helen Galley
Senior Lecturer in Anaesthesia & Intensive Care and Degree Programme Co-ordinator, Intercalated BSc in Medical Scienecs
PhD (Leeds, 1989), Fellowship of the Institute of Biomedical Science (London, 1984)
Personal Details
| Telephone: | +44 (0)1224 552775 |
| Fax: | +44 (0)1224 555766 |
| E-mail: | h.f.galley@abdn.ac.uk |
| Address: | Room 4.34 Institute of Medical Sciences Foresterhill UNiversity of Aberdeen AB25 2ZD +44 (0)1224 554533 (Secretary) +44 (0)1224 552775 (direct line) |
Web Links
http://www.abdn.ac.uk/esslemontgroup
http://www.abdn.ac.uk/medicine/prospective/aberdeen/intercalated
Biography
Helen Galley obtained her PhD in human zinc metabolism from the University of Leeds in 1989. She developed an interest in free radicals and antioxidants and later became involved in intensive care and liver transplantation research. Dr Galley was appointed to the post of Lecturer in Anaesthesia & Intensive Care in Aberdeen in 1995 and was promoted to Senior Lecturer in 2000. Dr Galley has published on a wide range of topics and her research interests now focus on modulation of inflammatory and immune responses in the critically ill.
Dr Galley teaches on BSc, MSc and MBChB courses and is Degree Programme Co-ordinator for the intercalated BSc in Medical Sciences. She reviews for a number of basic science, anaesthesia and critical care journals and is the editor of a series of books called Critical Care Focus. Dr Galley is an Editor of the British Journal of Anaesthesia; a member of the Research Committee of the Intensive Care Society and a member of the Allied Health Professionals Sub-Committee. She is an elected member of Council of the Anaesthetic Research Society and holds the office of Grants Officer. In 2002 she was awarded the Sir Humprey Davy medal by the Royal College of Anaesthetists for her services to Anaesthesia Research in the UK.
Research Interests
Mechanisms of the inflammatory and immune responses in the critically ill and their modulation. Current studies: Interaction between anaesthesia and nitric oxide; modulation of immune responses by anaesthetics, analgesic agents and antibiotics; genetic regulation of immune mediators; regulation of transcriptional activation.
Current Research
Current studies: Modulation of immune responses by anaesthetics, analgesic agents and antibiotics; genetic regulation of immune mediators; regulation of transcriptional activation; mitochondrial protection by antioxidants and prevention of organ failure; systems biology approaches to mechanisms of anaesthesia.
Collaborations
Dr Mike Murphy, MRC Mitochondrial Biology Unit, Cambridge (mitochondrial antioxidants).
Professor Bill Wisden, Dr Alessandro Moura (systems biology and anaesthesia).
Professor Mervyn Singer, UCL (mitochondrial function/sepsis)
Dr Jen Cleland (medical education)
Dr John Beattie, Rowett Institute of Nutritiona and Health (zinc studies)
Professor Neil Gow (candida and inflammation)
Professor Mike Rogers (gamma delta T cells)
Research Grants
Medical Research Council |
Mitochondrial targeted antioxidants and sepsis 2008-2011 |
National Institute of Academic Anaesthesia |
Polymorphisms of SPA adn SP-D in patients with ventilator associated pneumonia. 2009-2011 |
Scottish Government/Womens Aid |
Teaching medical students about domestic abuse 2009-2010 |
Intensive Care Society |
Is there a role for zinc in the inflammatory response to sepsis? 2010-2013 |
Teaching Responsibilities
Programme co-ordinator, Intercalated BSc Medical Sciences
Lectures on various BSc and MSc courses.
External Responsibilities
Member of the Board of Management of the British Journal of Anaesthesia and Editor (Laboratory and Basic Science Studies ).
Member of Council of the Anaesthetic Research Society and Grants Officer.
Member of the Intensive Care Society Research Committtee and member of the Allied Health Professional Sub-Committee.
Member of the North of Scotland Local Research Ethics Committee.
Selected Publications
(From 2000)
Papers
Paterson RL, Galley HF, Dhillon JK, Webster NR. Increased nuclear factor kappa B activation in critically ill patients who die. Crit Care Med 2000; 28: 1047-1051.
Galley HF, Blaylock MG, Dubbels AM, Webster NR. Variability in E-selectin expresssion, mRNA levels and sE-selectin release between endothelial cell lines and primary endothelial cells. Cell Biol Internat 2000; 24: 91-99.
Cuthbertson BH, Galley HF, Webster NR. Effect of inhaled nitric oxide on key mediators of the inflammatory response in patients with acute lung injury. Crit Care Med 2000; 28: 1736-1741.
Galley HF, Dhillon JK, Paterson RL, Webster NR. Effect of ciprofloxacin on the activation of the transcription factors NFkB, AP-1 and NF-IL-6, and interleukin-6 and interleukin-8 mRNA expression in a human endothelial cell line. Clin Sci 2000; 99: 405-410.
Galley HF, LeCras AE, Logan SD, Webster NR. Differential nitric oxide synthase activity, co-factor availability and cGMP accumulation in the central nervous system during anaesthesia. Br J Anaesth 2001; 86: 388-9.
Galley HF, LeCras AE, Yassen K, Grant IS, Webster NR. Circulating tetrahydrobiopterin concentrations during human septic shock. Br J Anaesth 2001; 86: 578-80.
Yassen KA, Galley HF, Webster NR. Matrix metalloproteinase-9 in critically ill patients. Anaesthesia 2001; 56: 729-32.
Galley HF, Macaulay GD, Webster NR. Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 and tumour necrosis factor a during cardiopulmonary bypass. Anaesthesia 2002; 57: 659-62.
Engelhardt T, Galley HF, MacLennan FM, Webster NR. Saliva cyclic GMP increases during anaesthesia. Br J Anaesth 2002: 89: 635-7.
Lowe PR, Galley HF, Webster NR. Influence of interleukin-10 polymorphisms on interleukin-10 expression and survival in critically ill patients. Crit Care Med 2003; 31: 34-8.
Paterson RL, Galley HF, Webster NR. The effect of N-acetylcysteine on nuclear factor kB activation, interleukin-6, interleukin-8 and intercellular adhesion molecule-1 expression in patients with sepsis. Crit Care Med 2003; 31: 2574-8.
Galley HF, Lowe PR, Carmichael RL, Webster NR. Genotype and interleukin-10 responses during cardiopulmonary bypass. Br J Anaesth 2003; 91: 424-6.
Williams AC, Galley HF, Webster NR. Differential effects of three antibiotics on T helper cell cytokine expression J Antimicrob Chemother 2005 ; 56: 502-6.
Lowes DA, Galley HF, Lowe PR, Rikke BA, Johnson TE, Webster NR. A microarray analysis of potential genes underlying the neurosensitivity of mice to propofol.Anesth Analg 2005 101: 697-704.
Engelhardt T, MacDonald J, GalleyHF, Webster NR. Selective phosphodiesterase 5 inhibition does no reduce propofol sedation requirements but affects speed of recovery and plasma cGMP concentrations in healthy volunteers. Anesth Analg 2005; 1012: 1050-3.
Engelhardt T, Lowe PR, Galley HF, Webster NR. Inhibition of neuronal nitric oxide synthase reduces motor activity even in nNOS knockout mice. Br J Anaesth 2006 96: 361-6.
Engelhardt T, Lowe PR, Galley HF, Webster NR. Inhibition of neuronal nitric oxide synthase reduces the propofol requirements in wild type and nNOS knockout mice. Eur J Anaes 2006; 23: 197-201.
Elsakka N, Galley HF, Sharaki O, Helmy M, Marsouk S, Sedrak M, Webster NR. Delayed apoptosis in patients with multiple organ dysfunction. Critical Care Shock 2006; 9: 9-15.
Madhy AM, Lowes DA, Galley HF, Webster NR. The production of soluble triggering receptor expressed on myeloid cells by lipopolysaccharide-stimulated human neutrophils involves de novo protein synthesis. Clin Vaccine Immunol 2006; 13: 492-5.
El Sakka NE, Webster NR, Galley HF. Polymorphism in the manganese superoxide dismutase gene. Free Rad Res 2007; 41: 770-8.
Galley HF, El Sakka NE, Lowes DA, Webster NR, Cuthbertson BH. Activated protein C inhibits chemotaxis and interleukin-6 release by human neutrophils without affecting other neutrophil functions. Br J Anaesth 2008; 100: 815-819. 2.
Lowes DA, Thottakam BMVJ, Webster NR, Murphy MP, Galley HF. The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis. Free Rad Biol Med 2008; 45: 1559-1565. 3.
Lowes DA, Wallace C, Webster NR, Galley HF. The mitochondria targeted antioxidant MitoQ protects against fluoroquinolone induced oxidative stress and mitochondrial membrane damage in human Achilles' tendon cells. Free Rad Res 2009; 43: 323-328.
Lowes DA, Webster NR, Galley HF. Dehydroascorbic acid as a pro-oxidant in an in vitro model of sepsis. Free Rad Res [in press].
Reviews etc
Galley HF, DiMatteo MA, Webster NR. Immunomodulation by anaesthetic, sedative and analgesic agents: does it matter? Intensive Care Med 2000; 26: 267-274.
Galley HF. Can acute renal failure be prevented? J Royal Coll Surg Ed 2000; 45: 44-50.
Webster NR, Galley HF. Nutrition in the critically ill patient. J Royal Coll Surg Ed 2000; 45: 373-9.
Galley HF. Renal-dose dopamine: will the message now get through? Lancet 2000; 356: 2112-3
MacDonald J, Galley HF, Webster NR. Oxidative stress and cardiovascular dysfunction in sepsis. Crit Care Shock 2002; 2: 104-119.
MacDonald J, Galley HF, Webster NR. Oxidative stress and gene expression in sepsis. Br J Anaesth 2003; 90: 221-32.
Galley HF, Lowe PR. Fishing in the gene pool. Crit Care Med 2003; 31: 317-8.
Galley HF. Systematic scepticism. Crit Care Med 2003; 31: 1284-5.
Webster NR, Galley HF. Inflammation. Br J Anaesth CEPD Reviews 2003; 3: 54-8.
Galley HF, Webster NR. Physiology of the endothelium. Br J Anaesth 2004; 93: 105-13.
Galley HF. Solid as a ROC. Br J Anaesth 2004; 93: 623-6.
Galley HF, Mahdy AM, Lowes DA. Pharmacogenetics and anesthesiologists. Pharmacogenom 2005; 6: 849-56.
Galley HF. What's in a name? Br J Anaesth 2008; 100: 151-3.
Galley HF, Hall B. Films, Facts and Fiction. Anaesthesia 2008; 60: 692-4.
Webster NR, Galley HF. Does strict glucose control improve outcome? Br J Anaesth 2009; 103: 331-4
Webster NR, Galley HF. Immunomodulation in the critically ill. Br J Anaesth 2009 103: 70-81.
Books
Galley HF (editor). Critical Care Focus volume 1. Renal Failure. BMJ Books, London, 1999.
Galley HF (editor). Critical Care Focus volume 2. Respiratory Failure. BMJ Books, London, 1999.
Galley HF (editor). Critical Care Focus volume 3. Neurological injury. BMJ Books, London, 2000.
Galley HF (editor). Critical Care Focus volume 4. Endocrine disturbance. BMJ Books, London, 2000.
Galley HF (editor). Critical Care Focus volume 5. Antibiotic resistance and infection control. BMJ Books, London, 2001.
Galley HF (editor). Critical Care Focus volume 6. Cardiology in the critically ill. BMJ Books, London, 2001.
Galley HF (editor). Critical Care Focus volume 7. Nutritional issues. BMJ Books, London, 2001.
Galley HF (editor). Critical Care Focus volume 8. Haemoglobin, transfusion and haemostasis. BMJ Books, London, 2002.
Galley HF (editor). Critical Care Focus volume 9. The gut. BMJ Books, London, 2002.
Galley HF (editor). Critical Care Focus volume 10. Immunity and inflammation. BMJ Books, London, 2002.
Galley HF (editor). Critical Care Focus volume 11. Trauma. BMJ Books, London, 2004.
Webster NR, Galley HF (editors). Anaesthesia Sciences. Blackwell, Oxford 2006.
Galley HF, Webster NR (editors). Classic Papers in Anaesthesia. Oxford University Press, Oxford [in press].