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WELCOME TO ALLEGRO

A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery : The ALLEGRO trial

COVID-19 update

10th July 2020: Recruitment to ALLEGRO has now restarted at some centres.

In response to COVID-19, we have paused patient recruitment into this study. We are continuing to follow-up people who are already taking part. It may be that we are in touch with you by a different method than usual (for example we may telephone you to complete questionnaires, rather than send them by post). If you have any questions about the study, please email. allegro@abdn.ac.uk .

If you are a patient and require medical attention or advice, please contact your GP or NHS-111/NHS-24 (by dialling 111).

You can also find information about COVID-19 from the NHS websites in England ,Scotland, Wales and Northern Ireland.

There is also information about COVID-19 on the UK government website.

What is ALLEGRO?

ALLEGRO is a research study investigating if Intravenous (IV) Lidocaine improves recovery of gut function after colorectal surgery for NHS patients.

A common problem in about 40% of patients having colorectal (large bowel) surgery is that their gut takes longer than normal to start working again. In most patients the gut will start working after surgery in 2-3 days, but in some it takes a week or more. This delayed recovery causes nausea, vomiting, complete constipation, tummy pain and tummy swelling and can take days to improve. During this time patients have to stay in hospital with a continuous intravenous drip and often need insertion of a nasogastric tube to empty the stomach to reduce vomiting (most patients find this very unpleasant).

Lidocaine (a local anesthetic) used intravenously (through the vein) has been shown to reduce pain and inflammation after surgery and seems to help other aspects of recovery that may be important for return of gut function, for example reducing nausea and vomiting.


The Allegro study hopes to find out if Lidocaine can help improve the recovery of gut function in patients after bowel surgery. Half of the people who agree to take part in Allegro will receive the IV lidocaine and half will receive a placebo (or dummy) IV. We will then compare the two groups and see whether gut function returns more quickly in the group who have received IV lidocaine.
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Study news

Recruitment

288/2080

Can I take part?

We are recruiting patients at hospitals in the UK. You may be eligible to take part in ALLEGRO if:

• You are aged 18 or over,
• You are scheduled for colorectal resection at participating surgery units
• You have no contraindications to Lidocaine.


If the hospital you have been referred to for your colorectal surgery is participating in ALLEGRO, your surgeon may discuss the study with you at your hospital visit.

If you would like any more information about ALLEGRO, including information about taking part, please contact the study office at the University of Edinburgh on 0131 ###### or use the contact us form found below.

If you are interested in taking part, or have any questions

Where can I take part?

Edinburgh

Key people:

Investigator:

  • Mr Hugh Paterson

Address:

Western General Hospital
Colorectal Surgery Unit
Crewe Road
Edinburgh
EH4 2XU
East Lancs Hospital NHS Trust

Key people:

Investigator:

  • Mr Anton Krige

Address:

East Lancs Hospital NHS Trust
Royal Blackburn Hospital
Blackburn
Lancashire
BB2 3HH
The Rotherham NHS Foundation Trust

Key people:

Investigator:

  • Mr Anil Hormis

Address:

Rotherham NHS Foundation Trust
Rotherham Hospital
Moorgate
Rotherham
S60 2UD
Royal Berkshire Hospital NHS Foundation Trust

Key people:

Investigator:

  • Mr Doug Barker

Address:

Royal Berkshire Hospital
London Road
Reading
Berkshire
RG1 5AN
Norfolk & Norwich University Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr James Hernan

Address:

Norfolk and Norwich University Hospitals trust
Colney Lane
Norwich
Norfolk
NR4 7UY
Medway NHS Foundation Trust

Key people:

Investigator:

  • Ms Samantha Black

Address:

Medway Maritime Hospital
Gatehouse Lodge
Windmill Road
Gillingham, Kent
ME7 5NY
Belfast Health and Social Care Trust

Key people:

Investigator:

  • Mr Jason Brooks

Address:

Belfast City Hospital
51 Lisburn Road
Belfast
BT9 7AB
The Newcastle upon Tyne Hospitals

Key people:

Investigator:

  • Mr Richard Brady

Address:

Freeman Hospital
Newcastle upon Tyne
Freeman Road
High Heaton, Newcastle upon Tyne
NE7 7DN
South Tees Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr Andrew Lloyd

Address:

James Cook University Hospital
Marton Road
Middlesbrough
TS4 3BW
North Tees and Hartlepool NHS Foundation Trust

Key people:

Investigator:

  • Mr John Francis

Address:

1st Floor, Middlefield Centre
University Hospital of North Tees
Hardwick
Stockton on Tees
TS19 8PE
Yeovil District Hospital

Key people:

Investigator:

  • Ms Agnieszka Kubisz-Pudelko

Address:

Yeovil District Hospital NHS Foundation Trust
Yeovil District Hospital
Higher Kingston
Yeovil, Somerset
BA21 4AT
Cardiff and Vale University Health Board

Key people:

Investigator:

  • Mr Michael Davies

Address:

University Hospital of Wales
Colorectal Surgery Unit
Heath Park
Cardiff
CF14 4XW
Mid Essex Hospital Services NHS Trust

Key people:

Investigator:

  • Mr Al Hughes

Address:

Broomfield Hospital
Court Road
Chelmsford
Essex
CM1 7ET
NHS Greater Glasgow and Clyde

Key people:

Investigator:

  • Mr Gary Nicholson

Address:

Queen Elizabeth University Hospital
1345 Govan Road
Govan
Glasgow
G51 4TF
Wirral University Teaching Hospital NHS Foundation Trust

Key people:

Investigator:

  • Ms Heather Black

Address:

Arrowe Park Hospital
Arrowe Park Road
Upton
Wirral
CH49 5PE
Cambridge University Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Ms Nicola Fearnhead

Address:

Cambridge University Hospitals NHS Foundation Trus
Addenbrooke's Hospital
Box 414, Flat 34, Coton House Cambridge Biomedical
Hills Road Cambridge
CB2 0QQ
St Georges Healthcare NHS Foundation Trust

Key people:

Investigator:

  • Nirav Shah

Address:

St Georges Hospital
Blackshaw Road
Tooting
London
SW17 0QT
Peterborough City Hospital

Key people:

Investigator:

  • Mr Robert Dennis

Address:

Peterborough City Hospital
Edith Cavell Campus
Bretton Gate
Peterborough
PE3 9GZ
Queen Elizabeth Hospital, Birmingham

Key people:

Investigator:

  • Jaimin Patel

Address:

Queen Elizabeth Hospital
Mindelsohn Way
Edgbaston
Birmingham
B15 2TH
Liverpool University Hospitals NHS Foundation Trust - coming soon

Key people:

Investigator:

  • Mr Richard Ramsaran

Address:

The Royal Liverpool and Broadgreen University Hosp
Royal Liverpool University Hospital
Prescott Street
Liverpool
L7 8XP
St Mary's Hospital - Imperial College Healthcare NHS Trust

Key people:

Investigator:

  • Mr Nicholas Gilfillan

Address:

Salton House
St. Mary’s Hospital
Praed Street
London
W2 1NY
Manchester Royal Infirmary - coming soon

Key people:

Investigator:

  • Mr James Hill

Address:

Manchester University NHS Foundation Trust
Manchester Royal Infirmary
Oxford Road
Manchester
M13 9WL
Manchester University NHS Foundation Trust - Wythenshawe Site - coming soon

Key people:

Investigator:

  • Ms Sarah Duff

Address:

Manchester University NHS Foundation Trust
Wythenshawe Hospital
Southmoor Road
Wythenshawe, Manchester
M23 9QZ
Worcestershire Acute Hospitals NHS Trust

Key people:

Investigator:

  • Miss Pamela Sivathondan

Address:

Alexandra Hospital
Woodrow Drive
Redditch
Worcestershire
B98 7UB
St James’ University Hospital

Key people:

Investigator:

  • Mr Aaron Quyn

Address:

The Leeds Teaching Hospitals NHS Trust
St. James's University Hospital
Beckett Street
Leeds
LS9 7TF
Royal Alexandria Hospital - Paisley

Key people:

Investigator:

  • Ms Susan Moug

Address:

NHS Greater Glasgow and Clyde
Royal Alexandra Hospital​
Corsebar Road
Paisley, Renfrewshire
PA2 9PN
Dorset County Hospital

Key people:

Investigator:

  • Mr Duncan Farquhar-Thomason

Address:

Damers House
Dorset County Hospital
Damers Road
Dorchester, Dorset
DT1 2JY
Southmead Hospital, North Bristol - coming soon

Key people:

Investigator:

  • Ms Anne Pullyblank

Address:

Southmead Hospital
Beaufort Way
Westbury-on-Trym
Bristol
BS10 5NB
Torbay Hospital - coming soon

Key people:

Investigator:

  • Dr Thomas Clark

Address:

Torbay & South Devon NHS Foundation Trust
Torbay Hospital
Lowes Bridge
Torquay, Devon
TQ2 7AA
Royal Devon and Exeter NHS Foundation Trust - coming soon

Key people:

Investigator:

  • Mr Alex Mills

Address:

Royal Devon & Exeter NHS Foundation Trust
Royal Devon and Exeter Hospital
Barrack Road
Exeter
EX2 5DW
Royal Bournemouth Hospital - coming soon

Key people:

Investigator:

  • Dr James Craig

Address:

The Royal Bournemouth & Christchurch Hospitals NHS
Royal Bournemouth Hospital
Castle Lane East
Bournemouth
BH7 7DW

Key facts about the study and documents

What is this study about?

If you are eligible and would like to take part in the ALLEGRO study you will be recruited at your local hospital (please see the section ‘Where can I take part? to check if your local hospital is participating).

If you want to take part we will ask you to sign a consent form and answer some questions about your health. We will also ask you to complete a study questionnaire.


After this we will randomize you to receive either
•    Intravenous Lidocaine during your operation or
•    Intravenous placebo (dummy) during your operation.

Throughout your stay in hospital we will ask you questions about any pain or. Nausea, your ability to eat and drink and other aspects of your recovery. Following discharge we will contact you by telephone 30 days and 90 days after your surgery and ask you some questions about your recovery.

You can find out more information about ALLEGRO here:

Download documents:

Key contacts

Click on cards to find out more

Organisation

ALLEGRO has been funded by the National Institute for Health Research. For more information please visit www.nets.nihr.ac.uk.