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WELCOME TO ALLEGRO

A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery : The ALLEGRO trial

What is ALLEGRO?

ALLEGRO is a research study investigating if Intravenous (IV) Lidocaine improves recovery of gut function after colorectal surgery for NHS patients.

A common problem in about 40% of patients having colorectal (large bowel) surgery is that their gut takes longer than normal to start working again. In most patients the gut will start working after surgery in 2-3 days, but in some it takes a week or more. This delayed recovery causes nausea, vomiting, complete constipation, tummy pain and tummy swelling and can take days to improve. During this time patients have to stay in hospital with a continuous intravenous drip and often need insertion of a nasogastric tube to empty the stomach to reduce vomiting (most patients find this very unpleasant).

Lidocaine (a local anesthetic) used intravenously (through the vein) has been shown to reduce pain and inflammation after surgery and seems to help other aspects of recovery that may be important for return of gut function, for example reducing nausea and vomiting.


The Allegro study hopes to find out if Lidocaine can help improve the recovery of gut function in patients after bowel surgery. Half of the people who agree to take part in Allegro will receive the IV lidocaine and half will receive a placebo (or dummy) IV. We will then compare the two groups and see whether gut function returns more quickly in the group who have received IV lidocaine.
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Study news

Recruitment

81/2080

Can I take part?

We are recruiting patients at hospitals in the UK. You may be eligible to take part in ALLEGRO if:

• You are aged 18 or over,
• You are scheduled for colorectal resection at participating surgery units
• You have no contraindications to Lidocaine.


If the hospital you have been referred to for your colorectal surgery is participating in ALLEGRO, your surgeon may discuss the study with you at your hospital visit.

If you would like any more information about ALLEGRO, including information about taking part, please contact the study office at the University of Edinburgh on 0131 ###### or use the contact us form found below.

If you are interested in taking part, or have any questions

Where can I take part?

Edinburgh

Key people:

Investigator:

  • Mr Hugh Paterson

Address:

Western General Hospital
Colorectal Surgery Unit
Crewe Road
Edinburgh
EH$ 2XU
East Lancs Hospital NHS Trust

Key people:

Investigator:

  • Mr Anton Krige

Address:

East Lancs Hospital NHS Trust
Royal Blackburn Hospital
Blackburn
Lancashire
BB2 3HH
The Rotherham NHS Foundation Trust

Key people:

Investigator:

  • Mr Anil Hormis

Address:

Rotherham NHS Foundation Trust
Rotherham Hospital
Moorgate
Rotherham
S60 2UD
Royal Berkshire Hospital NHS Foundation Trust

Key people:

Investigator:

  • Mr Doug Barker

Address:

Royal Berkshire Hospital
London Road
Reading
Berkshire
RG1 5AN
Norfolk & Norwich University Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr James Hernan

Address:

Norfolk and Norwich University Hospitals trust
Colney Lane
Norwich
Norfolk
NR4 7UY
Medway NHS Foundation Trust

Key people:

Investigator:

  • Ms Samantha Black

Address:

Medway Maritime Hospital
Gatehouse Lodge
Windmill Road
Gillingham, Kent
ME7 5NY
Belfast Health and Social Care Trust

Key people:

Investigator:

  • Mr Jason Brooks

Address:

Belfast City Hospital
51 Lisburn Road
Belfast
BT9 7AB
The newcastle upon Tyne Hospitals - coming soon

Key people:

Investigator:

  • Mr Richard Brady

Address:

Freeman Hospital
Newcastle upon Tyne
Freeman Road
High Heaton, Newcastle upon Tyne
NE7 7DN
South Tees Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr Andrew Lloyd

Address:

James Cook University Hospital
Marton Road
Middlesbrough
TS4 3BW
North Tees and Hartlepool NHS Foundation Trust

Key people:

Investigator:

  • Mr John Francis

Address:

1st Floor, Middlefield Centre
University Hospital of North Tees
Hardwick
Stockton on Tees
TS19 8PE
Yeovil District Hospital

Key people:

Investigator:

  • Ms Agnieszka Kubisz-Pudelko

Address:

Yeovil District Hospital NHS Foundation Trust
Higher Kingston
Yeovil
Somerset
BA21 4AT
Cardiff and Vale University Health Board

Key people:

Investigator:

  • Mr Michael Davies

Address:

University Hospital of Wales
Colorectal Surgery Unit
Heath Park
Cardiff
CF14 4XW
Mid Essex Hospital Services NHS Trust

Key people:

Investigator:

  • Mr Al Hughes

Address:

Broomfield Hospital
Court Road
Chelmsford
Essex
CM1 7ET
NHS Greater Glasgow and Clyde

Key people:

Investigator:

  • Mr Gary Nicholson

Address:

Queen Elizabeth University Hospital
1345 Govan Road
Govan
Glasgow
G51 4TF
Wirral University Teaching Hospital NHS Foundation Trust

Key people:

Investigator:

  • Ms Heather Black

Address:

Arrowe Park Road
Upton
Wirral
CH49 5PE
Cambridge University Hospitals NHS Foundation Trust - coming soon

Key people:

Investigator:

  • Ms Nicola Fearnhead

Address:

St Georges Healthcare NHS Foundation Trust - coming soon

Key people:

Investigator:

  • Nirav Shah

Address:

St Georges Hospital
Blackshaw Road
Tooting
London
SW17 0QT
Peterborough City Hospital - coming soon

Key people:

Investigator:

  • Mr Robert Dennis

Address:

Edith Cavell Campus
Bretton Gate
Peterborough
PE3 9GZ

Key facts about the study and documents

What is this study about?

If you are eligible and would like to take part in the ALLEGRO study you will be recruited at your local hospital (please see the section ‘Where can I take part? to check if your local hospital is participating).

If you want to take part we will ask you to sign a consent form and answer some questions about your health. We will also ask you to complete a study questionnaire.


After this we will randomize you to receive either
•    Intravenous Lidocaine during your operation or
•    Intravenous placebo (dummy) during your operation.

Throughout your stay in hospital we will ask you questions about any pain or. Nausea, your ability to eat and drink and other aspects of your recovery. Following discharge we will contact you by telephone 30 days and 90 days after your surgery and ask you some questions about your recovery.

You can find out more information about ALLEGRO here:

Download documents:

Key contacts

Click on cards to find out more

Organisation

ALLEGRO has been funded by the National Institute for Health Research. For more information please visit www.nets.nihr.ac.uk.