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What is ESP2?

Multi-centre trials provide key evidence underpinning healthcare practice. However, they invariably take a lot of hard work and expense to complete, with some of this work and expense being devoted to sites that under-recruit. Developing practical methods to identify sites that will recruit to target would be helpful.

ESP2 aims to evaluate a guided site performance prediction tool for trial managers. The tool was developed during the initial ESP study using practical experience from trial managers. Trial managers were asked to identify reasons why sites might fail to recruit to target in randomised and non-randomised interventional trials.


ESP identified eight possible 'red flags' to predict recruitment failure at a site:
• previous poor site performance
• slow approvals process
• strong staff/patient preferences
• the site recruitment target
• the trial protocol and its implementation at the site
• lack of staff engagement
• lack of research experience among site staff; busy site staff.

We have used these identified flags to develop a site performance prediction tool. We hope that using this tool will improve the accuracy of trial managers’ predictions about site recruitment performance, but this needs evaluation. It is this evaluation that ESP2 will conduct.

To evaluate the tool, we need trial managers to make 1000 site performance predictions (will the site recruit to target yes or no?). We invite trial managers working in anywhere in the world to register and start making predictions! If you’d like more information, scroll down.

ESP2 is a collaboration between University of Aberdeen, Trial Forge and the UK Trial Managers' Network.
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Can I take part and registration

You can take part in ESP2 if:

  1. You are responsible (e.g. as a Trial Manager, Trial Manager Assistant or Clinical Research Associate) for setting up trial recruitment sites and carrying out site initiation training with site staff.
  2. Your trial is currently opening new recruitment sites. You will be able to make predictions between October 2019 and until September 2021.
  3. Your trial is testing one or more interventions. Your trial can be randomised or non-randomised but cannot be cluster randomised.
  4. You and your trial recruitment sites can be anywhere in the world.
  5. You are willing to make at least one prediction. There is no limit to the number of predictions you can make


If you would like more information about ESP2, including information about taking part, please contact the study team using the contact us link below or email us on ESP2@abdn.ac.uk Or you can just register to take part using the link below.

ESP2 started in 2019 and is expected to run until 2022.

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If you are interested in taking part, or have any questions

Where are people already taking part?

Bristol Trials Centre, Clinical Trials and Evaluation Unit

Key people:

Organisation:

  • Bristol Trials Centre, Clinical Trials and Evaluation Unit

Address:

Level 7 Queens Building
Bristol Royal Infirmary
Bristol
BS2 8HW
University of York

Key people:

Organisation:

  • University of York

Address:

York Trials Unit
ARCC Building
Yorkshire and the Humber
YO10 5DD
Liverpool Clinical Trials Centre (University of Liverpool)

Key people:

Organisation:

  • Liverpool Clinical Trials Centre (University of Liverpool)

Address:

Liverpool Clinical Trials Centre, University of Liverpool, 2nd Floor, Institute in the Park, Alder He
Liverpool
L12 2AP
University of Birmingham

Key people:

Organisation:

  • University of Birmingham

Address:

Birmingham Clinical Trials Unit (BCTU)
Public Health Building
West Midlands
B19 2EL
ICNARC

Key people:

Organisation:

  • ICNARC

Address:

University of Oxford

Key people:

Organisation:

  • University of Oxford

Address:

NDORMS, Kadoorie Centre
Level 3, John Radcliffe Hospital
Headley Way
Oxfordshire
OX3 9DU
Edinburgh Clinical Trials Unit, University of Edinburgh,

Key people:

Organisation:

  • Edinburgh Clinical Trials Unit, University of Edinburgh,

Address:

Leeds Teaching Hospitals NHS Trust

Key people:

Organisation:

  • Leeds Teaching Hospitals NHS Trust

Address:

Surgical Research Office
Ground floor Lincoln Wing
St James' University Hospital
Beckett Street
LS9 7TF
University of Bristol

Key people:

Organisation:

  • University of Bristol

Address:

1-5 Whiteladies Road
BS8 1NU
ECTU

Key people:

Organisation:

  • ECTU

Address:

Usher Institute
University of Edinburgh
NINE Edinburgh BioQuarter
9 Little France Road
EH16 4UX
HSRU

Key people:

Organisation:

  • HSRU

Address:

Health Services Research Unit
University of Aberdeen
3rd Floor, Health Sciences Building
Foresterhill
AB25 2ZD
ECTU

Key people:

Organisation:

  • ECTU

Address:

University of Edinburgh

Key people:

Organisation:

  • University of Edinburgh

Address:

Edinburgh Clinical Trials Unit
Usher Institute
NINE Edinburgh BioQuarter
9 Little France Road
EH16 4UX
University of Bristol

Key people:

Organisation:

  • University of Bristol

Address:

3.12, Canynge Hall
39 Whatley Road
BS8 2PS
Edinburgh University

Key people:

Organisation:

  • Edinburgh University

Address:

Edinburgh Clinical Trials Unit
Usher Institut, 9 BioQuarter
9 Little France Road
Edinburgh
EH16 4UX
University of Oxford

Key people:

Organisation:

  • University of Oxford

Address:

Level 3 Kadoorie Centre, John Radcliffe Hospital
Headley Way
Oxfordshire
OX3 9DU
University of York

Key people:

Organisation:

  • University of York

Address:

York Trials Unit
Department of Health Sciences
ARRC Building
University of York
YO10 5DD
NHS Blood and Transplant

Key people:

Organisation:

  • NHS Blood and Transplant

Address:

University of Dundee

Key people:

Organisation:

  • University of Dundee

Address:

Tayside Clinical Trials Unit (TCTU)
School of Medicine
DD2 1UA
University of Oxford

Key people:

Organisation:

  • University of Oxford

Address:

Diabetes and Inflammation Laboratory
Wellcome Centre for Human Genetics
University of Oxford
Roosevelt Drive, Headington
OX37BN
Nottingham Clinical Trials Unit

Key people:

Organisation:

  • Nottingham Clinical Trials Unit

Address:

NCTU, Building 42
University Park
University of Nottingham
NG4 3EX
Queen Mary University of London

Key people:

Organisation:

  • Queen Mary University of London

Address:

Brighton and Sussex CTU

Key people:

Organisation:

  • Brighton and Sussex CTU

Address:

Room 204 Bevendean House
Village Way
Falmer
BN1 9PH
MRC Epidemiology Unit, University of Cambridge Schol of Clinical Medicint

Key people:

Organisation:

  • MRC Epidemiology Unit, University of Cambridge Schol of Clinical Medicint

Address:

Box 285 Institute of Metabolic Science
Cambridge Biomedical Campus
Cambridge
East of England
CB2 0QQ
McMaster University

Key people:

Organisation:

  • McMaster University

Address:

East London NHS Foundation Trust

Key people:

Organisation:

  • East London NHS Foundation Trust

Address:

Nottingham Clinical Trial Unit

Key people:

Organisation:

  • Nottingham Clinical Trial Unit

Address:

Nottingham Clinical Trials Unit
Building 42
Room A17
The University of Nottingham
NG72RD
University of Aberdeen

Key people:

Organisation:

  • University of Aberdeen

Address:

Imperial College London

Key people:

Organisation:

  • Imperial College London

Address:

Department of Surgery & Cancer
Imperial College London
Hammersmith Campus
ICTEM Building, 1st Floor
W12 0NN
Centre for Trials Research, Cardiff University

Key people:

Organisation:

  • Centre for Trials Research, Cardiff University

Address:

Centre for Trials Research
Cardiff University
7th Floor, Neuadd Meirionnydd
Heath Park
CF14 4YS
University of Aberdeen

Key people:

Organisation:

  • University of Aberdeen

Address:

Centre for Healthcare Randomised Trials (CHaRT), 3rd Floor, Health Sciences Building
University of Aberdeen, Foresterhill
AB25 2ZD
University of Oxford - Oxford Trauma

Key people:

Organisation:

  • University of Oxford - Oxford Trauma

Address:

UK

Key people:

Organisation:

  • UK

Address:

Social Science Research Unit, UCL Institute of Education
Room 201 18 Woburn Square
London, WC1H 0NR
WC1H 0NR
Nottingham Clinical Trials Unit

Key people:

Organisation:

  • Nottingham Clinical Trials Unit

Address:

Nottingham Clinical Trials Unit
Building 42
University Park
NG7 2RD
Afortiori Development Ltd

Key people:

Organisation:

  • Afortiori Development Ltd

Address:

University of Manchester

Key people:

Organisation:

  • University of Manchester

Address:

Room 1.309
Jean McFarlane Building
Oxford Road
M139PL
Ziekenhuis Oost-Limburg

Key people:

Organisation:

  • Ziekenhuis Oost-Limburg

Address:

Schiepse Bos 6
3600
University of Oxford

Key people:

Organisation:

  • University of Oxford

Address:

PC-CTU, Dept of Primary Care Sciences
University of Oxford
1st Floor Gibson Building, Radcliffe Observatory Quarter
Woodstock Road
OX2 6GG
Nottingham Clinical Trials Unit

Key people:

Organisation:

  • Nottingham Clinical Trials Unit

Address:

Nottingham Clinical Trials Unit
University of Nottingham
Building 42, University Park
NG7 2RD
University of Bristol

Key people:

Organisation:

  • University of Bristol

Address:

Bristol Trials Centre (CTEU)
Level 7, Queen's Building, Bristol Royal Infirmary
Bristol
South West
BS2 8HW
Surgical Intervention Trials Unit

Key people:

Organisation:

  • Surgical Intervention Trials Unit

Address:

Botnar Research Centre
Windmill Road
OX3 7LD
UHNM

Key people:

Organisation:

  • UHNM

Address:

Research and Innovation Directorate
Royal Stoke University Hospital
Newcastle Road
Stoke On-Trent
ST4 6QG
Clinical Trials Research Unit - Leeds University

Key people:

Organisation:

  • Clinical Trials Research Unit - Leeds University

Address:

Clinical Trials Research Unit
LS2 9JT
University of Leeds

Key people:

Organisation:

  • University of Leeds

Address:

LS2 9JT
University of Dundee

Key people:

Organisation:

  • University of Dundee

Address:

Tayside Medical Science Centre
George Pirie Way
Ninewells Hospital & Medical School
Tayside
DD1 9SY
University Hospitals Coventry & Warwickshire NHS Trust

Key people:

Organisation:

  • University Hospitals Coventry & Warwickshire NHS Trust

Address:

Research & Development
University Hospitals Coventry & Warwickshire
Clifford Bridge Road
CV2 2DX
Bristol Trials Centre (CTEU)

Key people:

Organisation:

  • Bristol Trials Centre (CTEU)

Address:

CTU, University Hospital Basel

Key people:

Organisation:

  • CTU, University Hospital Basel

Address:

Spitalstr. 12
4031
Clinical Trials Research Unit, University of Leeds

Key people:

Organisation:

  • Clinical Trials Research Unit, University of Leeds

Address:

Clinical Trials Research Unit
Leeds Institute of Clinical Trials Research
University of Leeds
LS2 9JT
Birmingham Clinical Trials Unit

Key people:

Organisation:

  • Birmingham Clinical Trials Unit

Address:

Leicester Clinical Trials Unit

Key people:

Organisation:

  • Leicester Clinical Trials Unit

Address:

University of Leicester
College of Life Sciences
Maurice Shock Building
University Road
LE1 7RH
University of Liverpool

Key people:

Organisation:

  • University of Liverpool

Address:

Liverpool Clinical Trials Centre, University of Liverpool, 1st Floor, Mersey Bio,
Bio and Life Science, Liverpool,
L69 7ZB
Keele University

Key people:

Organisation:

  • Keele University

Address:

University of Cambridge

Key people:

Organisation:

  • University of Cambridge

Address:

Strangeways Research Lab
Worts Causeway
CB1 8RN
University of Leicester

Key people:

Organisation:

  • University of Leicester

Address:

Leicester Clinical Trials Unit
Maurice Shock Building
University Road
LE1 7RH
Miss

Key people:

Organisation:

  • Miss

Address:

London School of Hygiene & Tropical Medicine
Keppel Street
London
WC1E 7HT
Newcastle Clinical Trials Unit

Key people:

Organisation:

  • Newcastle Clinical Trials Unit

Address:

NCTU
1-4 Claremont Terrace
Newcastle
NE2 4AE
Southampton Clinical Trials Unit

Key people:

Organisation:

  • Southampton Clinical Trials Unit

Address:

Southampton Clinical Trials Unit
MP131, Southampton General Hospital
Tremona Road
SO166YD
University of Aberdeen

Key people:

Organisation:

  • University of Aberdeen

Address:

CHaRT
Third Floor, HSB
Foresterhill
AB25 2ZD
University of Edinburgh

Key people:

Organisation:

  • University of Edinburgh

Address:

Centre for Clinical Brain Sciences (CCBS)
University of Edinburgh
Chancellor's Building Room FU30302/14
49 Little France Crescent
EH16 4SB
HRB Primary Care Clinical Trials Network

Key people:

Organisation:

  • HRB Primary Care Clinical Trials Network

Address:

NHMRC

Key people:

Organisation:

  • NHMRC

Address:

University of Michigan

Key people:

Organisation:

  • University of Michigan

Address:

48105
NHS Greater Glasgow and Clyde

Key people:

Organisation:

  • NHS Greater Glasgow and Clyde

Address:

CRUK Clinical Trials Unit
Beatson West of Scotland Cancer Centre
1053 Great Western Road
Glasgow
G12 OYN
Guy's and St Thomas' NHS Foundation Trust

Key people:

Organisation:

  • Guy's and St Thomas' NHS Foundation Trust

Address:

CRUK CTU Glasgow

Key people:

Organisation:

  • CRUK CTU Glasgow

Address:

Level 0, 1053 Great Western Road
BWoSCC
G12 0YN
Liverpool Clinical Trials Centre

Key people:

Organisation:

  • Liverpool Clinical Trials Centre

Address:

Study news

Number of Predictions

116/1000

Key facts about the study and documents

What is this study about?

Taking part in ESP2 would involve:

  1. Registering yourself and your trial(s) in a one-off simple registration on this website.
  2. Making a recruitment prediction on this website as soon as possible after completing site initiation training. The site does not need to be open for recruitment when the prediction is made, so long as the site initiation training has been done.

  3. You can make just one prediction, or many more, it’s up to you. We just ask that you enter all information needed for each prediction. Entering your prediction will take less than 10 minutes.
  4. The ESP2 team will be in contact 6 months later and then again 12 months later to see how recruitment actually went at each site for which you made a prediction..

For the full details about what is involved please have a look at the Participant Information Leaflet.

We've also prepared some videos about logging your predictions:

Key facts

Video Guides

To view video on full screen, click on full screen icon in bottom right-hand side of the video
 

Registering yourself with ESP2:

   

Your first log-in after registration:

   

Adding a trial to make predictions for:

   

Making a prediction:

   

Key contacts

Click on cards to find out more

Organisation

Funding acknowledgement
ESP2 is made possible by a collaboration between Trial Forge, the UK Trial Managers’ Network and not least all the Trial Managers who have or will make predictions. We are a bit of a grassroot phenomenon in that it has not been possible to secure project- specific funding but we will not let that stop us (and we do have a bit of funding).

Follow us or visit our social media channel:

General Data Protection Regulation (GDPR)
Participant Information

The University of Aberdeen is hosting this study based in the United Kingdom. We will be using information from you in order to undertake this study and will act as the data controller for this study. This means that we are responsible for looking after your information and using it properly. University of Aberdeen/NHS Grampian will keep identifiable information about you for at least 3 years after the study has finished.

Your rights to access, change or move your information are limited, as we need to manage your information in specific ways in order for the research to be reliable and accurate. If you withdraw from the study, we will keep the information about you that we have already obtained. To safeguard your rights, we will use the minimum personally-identifiable information possible.

You can find out more about how we use your information https://www.abdn.ac.uk/privacy.