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WELCOME TO THE FUTURE STUDY

Female Urgency, Trial of Urodynamics as Routine Evaluation; a superiority randomised clinical trial to evaluate the effectiveness and cost effectiveness of invasive urodynamic investigations in management of women with refractory overactive bladder symptoms

What is FUTURE?

FUTURE is a research study looking at how useful a special bladder test called ‘Urodynamics’ is at improving the treatment results for women affected by refractory overactive bladder (OAB).

OAB affects 12-14% (12 in every 100 women) of the adult female population in the UK. Symptoms include increased frequency (going to pass urine more frequently); urgency (being unable to hold-on); urgency incontinence (Urinary Leakage being unable to hold-on); and waking up at night to pass urine.

Although rarely life-threatening, OAB can have a considerable negative impact on patients’ quality of life, restricting their social life and ability to work, and up-to social isolation in severe cases.


OAB is first treated with lifestyle changes (such as reducing caffeine intake); pelvic floor exercises; bladder training and certain medications. Unfortunately these treatments do not work in 25-40% of patients (i.e. refractory OAB). These patients may be offered second line treatments such as injections of BOTOX into the bladder wall or sacral nerve modulation/ stimulation (an implant in the buttock which aim to regulate the bladder nerves in the lower spine).

Before recommending second line treatments, doctors are advised to perform a diagnostic invasive test called “Urodynamics” to confirm the diagnosis. The test involves passing a thin tube into the bladder and another one into the back passage to measure the bladder activity and episodes of urinary incontinence (UI).

Patients often find Urodynamics embarrassing and uncomfortable and some get cystitis after the test. When asked, patients felt the test could be justified if it improves the treatment outcomes. However, in almost 40% of patients, Urodynamics does not show the underlying cause of the bladder problem and therefore is unable to guide doctors and patients in their decision making.

The FUTURE study therefore aims to assess whether routinely performing Urodynamics, in addition to the standard comprehensive clinical assessment, improves the outcome of treatments in women with refractory OAB compared to comprehensive clinical assessment only. We also want to assess whether doing the test on everybody makes the best use of NHS resources.

The FUTURE study is funded by the National Institute for Health Research HTA programme. You can find out more about taking part in research here: https://www.nihr.ac.uk/patients-and-public/opportunities/current-opportunities.htm.

You can find out more information about OAB and options of treatments on the NICE website https://www.nice.org.uk/guidance/cg171.
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Can I take part?

You may be eligible to take part in FUTURE if:

  • you are female and aged 18 or over,
  • you have symptoms of overactive bladder for which conservative treatments (e.g. pelvic floor exercises and/or bladder training) and drug therapy have failed or have not been tolerated,
  • and you are being considered for second line treatment.

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If you would like to know more about FUTURE, including information about taking part please contact the study office at the University of Aberdeen on 01224 438405 or email future@abdn.ac.uk.

If you are interested in taking part, or have any questions?

Where can I take part?

NHS Grampian

Key people:

Investigator:

  • Dr Mohamed Abdel-fattah

Address:

Aberdeen Royal Infirmary
Foresterhill
Aberdeen
AB25 2ZN
NHS Fife

Key people:

Investigator:

  • Dr Chu Chin Lim

Address:

Victoria Hospital
Hayfield Road
Kirkaldy
KY2 5AH
NHS Borders

Key people:

Investigator:

  • Dr Kate Darlow

Address:

Borders General Hospital
Melrose
Roxburghshire
TD6 9BS
North Bristol NHS Trust - coming soon

Key people:

Investigator:

  • Mr Hashim Hashim

Address:

Southmead Hospital
Southmead Road
Westbury-on-Trym
Bristol
BS10 5NB
East Sussex Healthcase NHS Trust

Key people:

Investigator:

  • Mr Hosam Elhalwagy

Address:

Eastbourne District General Hospital
Kings Drive
Eastbourne
East Sussex
BN21 2UD
NHS Greater Glasgow & Clyde

Key people:

Investigator:

  • Dr Karen Guerrero

Address:

Queen Elizabeth University Hospital
1345 Govan Road
Glasgow
G51 4TF
Countess of Chester Hospital NHS Foundation Trust

Key people:

Investigator:

  • Dr Lorraine Dinardo

Address:

Countess of Chester Hospital
Liverpool Road
Chester
CH2 1UL
The Pennine Acute Hospitals NHS Trust

Key people:

Investigator:

  • Mr Zahid Hussain

Address:

The Royal Oldham Hospital
Rochdale Road
Oldham
OL1 2JH
Salford Royal NHS Foundation Trust

Key people:

Investigator:

  • Mr Chris Betts

Address:

Salford Royal NHS Foundation Trust
Stott Lane
Salford
M6 8HD
Liverpool Women's NHS Foundation Trust

Key people:

Investigator:

  • Miss Gillian Fowler

Address:

Liverpool Women’s Hospital
Liverpool Women’s NHS Foundation Trust
Crown Street
Liverpool
L8 7SS
The Newcastle upon Tyne Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Dr Karen Brown

Address:

Royal Victoria Infirmary
Queen Victoria Road
Newcastle Upon Tyne
NE1 4LP
City Hospitals Sunderland NHS Foundation Trust

Key people:

Investigator:

  • Miss Vivienne Kirchin

Address:

Sunderland Royal Hospital
Kayll Road
Sunderland
SR4 7TP
The Queen Elizabeth Hospital King's Lynn NHS Foundation Trust - coming soon

Key people:

Investigator:

  • Miss Ruth Doherty

Address:

Queen Elizabeth Hospital Kings Lynn
Gayton Road
Kings Lynn
PE30 4ET
South Tyneside NHS Foundation Trust

Key people:

Investigator:

  • Mr James Nwabineli

Address:

South Tyneside District Hospital
Harton Lane
South Sheilds
Tyne and Wear
NE34 0PL
City Hospitals Sunderland NHS Foundation Trust

Key people:

Investigator:

  • Miss Vivienne Kirchin

Address:

Sunderland Royal Hospital
Kayll Road
Sunderland
SR4 7TP
South Tees Hospital NHS Foundation Trust

Key people:

Investigator:

  • Mr Aethele Khunda

Address:

James Cook University Hospital
Marton Road
Middlesbrough
TS4 3BW
South Tees Hospital NHS Foundation Trust

Key people:

Investigator:

  • Mr Aethele Khunda

Address:

James Cook University Hospital
Marton Road
Middlesbrough
TS4 3BW
South Tees Hospital NHS Foundation Trust

Key people:

Investigator:

  • Mr Aethele Khunda

Address:

James Cook University Hospital
Marton Road
Middlesbrough
TS4 3BW
Sheffield Teaching Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr Christopher Chapple

Address:

Royal Hallamshire Hospital
Glossop Road
Sheffield
S10 2JF
University College London Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr Jeremy Ockrim

Address:

University College Hospital
16-18 Westmoreland Street
Marylebone
London
W1G 8PH
Northampton General Hospital NHS Trust

Key people:

Investigator:

  • Mrs Ami Shukla

Address:

Northampton General Hospital
Cliftonville
Northampton
NN1 5BD
Maidstone and Tunbridge Wells NHS Trust

Key people:

Investigator:

  • Mr Rowan Connell

Address:

Maidstone Hospital
Hermitage Lane
Maidstone
Kent
ME16 9QQ
Northern Health & Social Care Trust

Key people:

Investigator:

  • Mr Turlough Maguire

Address:

Antrim Area Hospital
Bush Road
Antrim
BT41 2RL
Plymouth Hospitals NHS Trust

Key people:

Investigator:

  • Dr Anu Dua

Address:

Derriford Hospital
Derriford Road
Crownhill
Plymouth
PL6 8DH
NHS Lothian

Key people:

Investigator:

  • Miss Voula Granitsiotis

Address:

Western General Hospital
Crewe Road South
Edinburgh
EH4 2XU
Manchester University NHS Foundation Trust

Key people:

Investigator:

  • Dr Karen Ward

Address:

St Marys Hospital
Oxford Road
Manchester
M13 9WL
University Hospital Southampton NHS Foundation Trust

Key people:

Investigator:

  • Mr Ash Monga

Address:

Princess Anne Hospital
Coxford Road
Southampton
SO16 5YA
Guy's and St Thomas' NHS Foundation Trust

Key people:

Investigator:

  • Mr Arun Sahai

Address:

Guys Hospital
Great Maze Pond
London
SE1 9RT
Hampshire Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr Christian Phillips

Address:

Basingstoke & North Hampshire Hospital
Aldermaston Road
Basingstoke
Hampshire
RG24 9NA
Bolton NHS Foundation Trust

Key people:

Investigator:

  • Dr Bim Williams

Address:

Royal Bolton Hospital
Minerva Road
Bolton
BL4 0JR
Kingston Hospital NHS Foundation Trust

Key people:

Investigator:

  • Mr Eduardo Cortes

Address:

Kingston Hospital
Galsworthy Road
Kingston upon Thames
KT2 7QB
NHS Forth Valley

Key people:

Investigator:

  • Mr Joby Taylor

Address:

Forth Valley Royal Hospital
Stirling Road
Larbert
FK5 4WR
The Leeds Teaching Hospitals NHS Trust

Key people:

Investigator:

  • Mr Syed Rahman

Address:

St James’s University Hospital
Beckett Street
Leeds
LS9 7TF
Portsmouth Hospitals NHS Trust

Key people:

Investigator:

  • Miss Claire Burton

Address:

Queen Alexandra Hospital,
Southwick Hill Road
Cosham
Hampshire
PO6 3LY
Nottingham University Hospitals NHS Trust

Key people:

Investigator:

  • Mr Asem Ali

Address:

City Hospital Campus
Hucknall Road
Nottingham
NG5 1PB
Calderdale and Huddersfield NHS Foundation Trust

Key people:

Investigator:

  • Dr Yi Ling Chan

Address:

Huddersfield Royal Infirmary
Lindley
Huddersfield
HD3 3EA
Airedale NHS Foundation Trust

Key people:

Investigator:

  • Mr Omer Baldo

Address:

Airedale General Hospital
Skipton Road
Steeton, Keighley
West Yorkshire
BD20 6TD
Bradford Teaching Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Dr Carmel Ramage

Address:

Bradford Royal Infirmary
Duckworth Lane
Bradford
BD9 6RJ
The Leeds Teaching Hospitals NHS Trust

Key people:

Investigator:

  • Mr Syed Rahman

Address:

St James’s University Hospital
Beckett Street
Leeds
LS9 7TF
Cambridge University Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr Nikesh Thiruchelvam

Address:

Addenbrooke Hospital
Cambridge Biomedical Campus
Hills Road
Cambrisge
CB2 0QQ
North West Anglia NHS Foundation Trust

Key people:

Investigator:

  • Mr Yves Van Roon

Address:

Hinchingbrooke Hospital
Hinchingbrooke Park
Huntingdon
Cambridgeshire
PE29 6NT
Milton Keynes University Hospital NHS Foundation Trust

Key people:

Investigator:

  • Miss Maryam Pezeshki

Address:

Milton Keynes University Hospital
Standing Way
Eaglestone
Milton Keynes
MK6 5LD
Great Western Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr Tamer Abdelrazik

Address:

Great Western Hospital
Marlborough Road
Swindon
SN3 6BB
Frimley Health NHS Foundation Trust

Key people:

Investigator:

  • Ms Gopalan Vijaya

Address:

Frimley Park Hospital
Maple House
Portsmouth Rd, Frimley
Surrey
GU16 7UJ
Stockport NHS Foundation Trust

Key people:

Investigator:

  • Ms Magda Kujawa

Address:

Stepping Hill Hospital
Poplar Grove
Hazel Grove
Stockport
SK2 7JE
St Helens and Knowsley Teaching Hospitals NHS Trust

Key people:

Investigator:

  • Mr Ahmed Omar

Address:

Whiston Hospital
Warrington Road
Prescot
L35 5DR
Royal United Hospitals Bath NHS Foundation Trust

Key people:

Investigator:

  • Mrs Aysha Qureshi

Address:

Royal United Hospital
Combe Park
Bath
BA1 3NG
The Royal Wolverhampton NHS Trust

Key people:

Investigator:

  • Mr Khaled Afifi

Address:

New Cross Hospital
Wolverhampton Road
Wolverhampton
West Midlands
WV10 0QP
Royal Devon and Exeter NHS Foundation Trust

Key people:

Investigator:

  • Mr John McGrath

Address:

Royal Devon and Exeter Hospital
Barrack Road
Exeter
EX2 5DW
Royal Cornwall Hospitals NHS Trust

Key people:

Investigator:

  • Miss Farah Lone

Address:

Royal Cornwall Hospital
Truro,
Cornwall
TR1 3HD
Oxford University Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Miss Natalia Price

Address:

John Radcliffe Hospital
Headley Way
Headington
Oxford
OX3 9DU
York Teaching Hospital NHS Foundation Trust

Key people:

Investigator:

  • Mr Mustafa Hilmy

Address:

York Teaching Hospital NHS Foundation Trust
Wigginton Road,
York
YO31 8HE
Brighton & Sussex University Hospitals NHS Trust

Key people:

Investigator:

  • Mr Sharif Ismail

Address:

Royal Sussex County Hospital
Eastern Road
Brighton
BN2 5BE
East Cheshire NHS Trust

Key people:

Investigator:

  • Dr Sara Nausheen

Address:

Macclesfield District General Hospital
Victoria Road
Macclesfield
SK10 3BL
University Hospitals of Leicester NHS Trust

Key people:

Investigator:

  • Prof Doug Tincello

Address:

Leicester Royal Infirmary,
Infirmary Square
Leicester
LE1 5WW
Basildon & Thurrock University Hopsitals NHS Foundation Trust

Key people:

Investigator:

  • Mr Yatin Thakur

Address:

Basildon University Hospita
Nethermayne
Basilon
Essex
SS16 5NL
Mid Yorkshire Hospitals NHS Trust

Key people:

Investigator:

  • Dr Ian Beckley

Address:

Pinderfields General Hospital
Aberford Road
Wakefield
WF1 4DG
Cardiff & Vale University Health Board

Key people:

Investigator:

  • Mr Oleg Tatarov

Address:

University Hospital of Wales
Health Park
Cardiff
CF14 4XW
Salisbury NHS Foundation Trust

Key people:

Investigator:

  • Miss Melissa Davies

Address:

Salisbury District Hospital
Salisbury
Wiltshire
SP2 8BJ
Wirral University Teaching Hospital NHS Foundation Trust

Key people:

Investigator:

  • Mr Mark Doyle

Address:

Arrowe Park Hospital
Upton Road
Wirral
Merseyside
CH49 5PE
NHS Highlands

Key people:

Investigator:

  • Dr Karina Laing

Address:

Centre for Health Science
Old Perth Road
Inverness
IV2 3JH
Wrightington, Wigan and Leigh NHS Foundation Trust

Key people:

Investigator:

  • Ms Jennifer Davies

Address:

Wrightington Hospital
Hall Lane
Appley Bridge
Wigan
WN6 9EP
NHS Lanarkshire

Key people:

Investigator:

  • Dr Adeeb Hassan

Address:

Wishaw General Hospital
50 Netherton
St. Wishaw
ML2 0DP
NHS Tayside

Key people:

Investigator:

  • Dr Sian Harvey

Address:

Ninewells Hospital
Dundee
DD1 9SY
Whittington Health NHS Trust - coming soon

Key people:

Investigator:

  • Dr Robert Sherwin

Address:

Whittington Hospital
Magdala Avenue
London
N19 5NF
Norfolk & Norwich Universiyt hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr Ilias Giarenis

Address:

Norwich & Norfolk University Hospital
Colney Lane
Norwich
NR4 7UY
Oxford University Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Miss Natalia Price

Address:

John Radcliffe Hospital
Oxford Road
Oxford
OX3 9DU
University Hospitals Coventry and Warwickshire NHS Trust

Key people:

Investigator:

  • Mr Iain Wharton

Address:

Study news

Recruitment

756/500

Trial sites

Latest addition to sites:

University Hospitals Coventry and Warwickshire NHS Trust
Oxford University Hospitals NHS Foundation Trust
Norfolk & Norwich Universiyt hospitals NHS Foundation Trust
NHS Tayside

Key facts about the study and documents

What is this study about?

If you are eligible and would like to part in the FUTURE study, you will discuss the study with your consultant as well as the local research nurse. (please see ‘Where can I take part?’ to check if your local hospital is participating).

If, after reading the participant information sheet and receiving satisfactory answers to all your questions, you would like to take part, you will be asked to sign the study consent form and answer some questions about your health.


You will then complete the study questionnaire and bladder diary in the privacy of your own home. After this, your research nurse will randomise you into the study i.e. you will be allocated (in random) to receive Urodynamics or not.

We will follow your progress for 15 months and we will send you the study questionnaire through the post (or email if you prefer) at 3, 6 and 15 months. The questionnaires are returned to the study office in a prepaid envelope which we provide.

You can find out more information on OAB/Urodynamics here: http://www.baus.org.uk/_userfiles/pages/files/Patients/Leaflets/Urodynamics14.pdf

Key contacts

Click on cards to find out more

Organisation

This project was funded by the National Institute for Health Research Health Technology Assessment (HTA) programme and is run by the University of Aberdeen, in conjunction NHS-Grampian. The views and opinions expressed therein are those of the authors and do not necessarily reflect those of National Institute for Health Research, NHS Grampian or University of Aberdeen. Please visit each organisation's website for more information.

General Data Protection Regulation (GDPR)
Participant Information

University of Aberdeen/NHS Grampian is the sponsor for this study based in the United Kingdom. We will be using information from you and your medical records in order to undertake this study and will act as the data controller for this study. This means that we are responsible for looking after your information and using it properly. University of Aberdeen/NHS Grampian will keep identifiable information about you at least 10 years after the study has finished.

Your rights to access, change or move your information are limited, as we need to manage your information in specific ways in order for the research to be reliable and accurate. If you withdraw from the study, we will keep the information about you that we have already obtained. To safeguard your rights, we will use the minimum personally-identifiable information possible.

You can find out more about how we use your information https://www.abdn.ac.uk/privacy.