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WELCOME TO THE PARTIAL STUDY

A randomised trial of the clinical and cost effectiveness of complex PARTIAL vs radical nephrectomy for clinically localised renal cell carcinoma.

What is PARTIAL?

PARTIAL is a research study looking at two different types of surgery for kidney cancer.

Every year, over 13,000 people in UK have a tumour on their kidney: some of these are a kidney cancer, others turn out not be a cancer. Often, these tumours are identified when they are at the early stages of growth (up to 7cm), and if there is no spread to other parts of the body there are two main types of surgery that can be done:
• Removal of the whole kidney if there is a normal kidney on the other side (radical nephrectomy)
• Partial removal of the kidney – only part of the kidney (where the tumour is) is removed (partial nephrectomy).


Each of these types of surgery have potential benefits and risks, but there is no good evidence for doctors and surgeons working in the NHS which operation is better. When surgeons remove part of the kidney, there is a higher chance of bleeding, but in the longer term, the person’s kidney function may be better. It is also unclear which type of surgery is the best option for patients.

The PARTIAL study will compare these two different types of surgery. Adults who consent to participate in PARTIAL will be randomly allocated to one of the two types of surgery mentioned above. We will keep in touch with participants for 24 months to collect information on several things, including how well the kidney(s) are working (through regular blood tests), any complications of surgery and quality of life.

The results of the PARTIAL study will help doctors, surgeons, patients and health services decision-makers understand whether it is better to remove the whole kidney or part of the kidney.
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Can I take part?

We are recruiting adults in the UK with suspected or confirmed stage T1 renal cell carcinoma (a type of kidney cancer), who are suitable to have either operation by keyhole surgery and are able and willing to give informed consent to participate.

Please see ‘Where can I take part?’ to check if your local hospital is participating.

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If you would like to know more about PARTIAL, including information about taking part, please contact the study office on 01224 438144 or email partial@abdn.ac.uk

If you are interested in taking part, or have any questions?

Where can I take part?

Newcastle upon Tyne Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr Rajan Veeratterapillay

Address:

Freeman Hospital
The Newcastle upon Tyne NHS Foundation Trust
Freeman Road, High Heaton
Newcastle upon Tyne
NE7 7DN
University Hospitals Coventry and Warwickshire NHS Trust

Key people:

Investigator:

  • Mr Anthony Blacker

Address:

University Hospital
Clifford Bridge Road
Coventry
CV2 2DX
Cambridge University Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Prof Grant Stewart

Address:

Addenbrooke's Hospital
Hills Road
Cambridge
CB2 0QQ
South Tyneside and Sunderland NHS Foundation Trust

Key people:

Investigator:

  • Mr Gareth Lewis

Address:

Sunderland Royal Hospital
Kayll Road
Sunderland
SR4 7TP
NHS Greater Glasgow and Clyde

Key people:

Investigator:

  • Mr Grenville Oades

Address:

Queen Elizabeth University Hospital
1345 Govan Road
Govan
Glasgow
G51 4TF
NHS Lothian

Key people:

Investigator:

  • Mr Alexander Laird

Address:

Western General Hospital
Crewe Rd South
Edinburgh
EH4 2XU
Cardiff and Vale University Health Board

Key people:

Investigator:

  • Mr Krishna Narahari

Address:

University Hospital of Wales
Heath Park
Cardiff
CF14 4XW
Royal Devon University Healthcare NHS Foundation Trust

Key people:

Investigator:

  • Mr Nick Campain

Address:

Royal Devon and Exeter Hospital
Barrack Road
Exeter
Devon
EX2 5DW
Guy's and St Thomas' NHS Foundation Trust

Key people:

Investigator:

  • Mr Ben Challacombe

Address:

Guy's Hospital
Great Maze Pond
London
Greater London
SE1 9RT
Nottingham University Hospitals NHS Trust

Key people:

Investigator:

  • Mr Thomas Walton

Address:

Nottingham City Hospital
Hucknall Road
Nottingham
NG5 1PB
University Hospitals of Leicester NHS Trust

Key people:

Investigator:

  • Mr Benjamin Jackson

Address:

Leicester General Hospital
Gwendolen Road
Leicester
Leicestershire
LE5 4PW
Manchester University NHS Foundation Trust

Key people:

Investigator:

  • Mr Bachar Zelhof

Address:

Manchester Royal Infirmary
Oxford Road
Manchester
M13 9WL
Royal Free London NHS Foundation Trust

Key people:

Investigator:

  • Prof Axel Bex

Address:

Royal Free Hospital
Pond Street
London
NW3 2QG
Stockport NHS Foundation Trust

Key people:

Investigator:

  • Mr Stephen Bromage

Address:

Stepping Hill Hospital
Poplar Grove
Stockport
Cheshire
SK2 7JE
The Leeds Teaching Hospitals NHS Trust

Key people:

Investigator:

  • Miss Anna Wright

Address:

St James's Hospital
Beckett Street
Leeds
LS9 7TF
University Hospitals Plymouth NHS Trust

Key people:

Investigator:

  • Mr Jack Coode-Bate

Address:

Derriford Hospital
Derriford Road
Crownhill
Plymouth
PL6 8DH
The Royal Wolverhampton NHS Trust

Key people:

Investigator:

  • Mr Aniruddha Chakravarti

Address:

Royal Wolverhampton Hospital
Wolverhampton Road
Wolverhampton
WV10 0QP
Mid and South Essex NHS Foundation Trust

Key people:

Investigator:

  • Mr Richard Tsung Chang

Address:

Southend University Hospital
Prittlewell Chase
Westcliff-on-Sea
Essex
SS0 0RY
Imperial College Healthcare NHS Trust

Key people:

Investigator:

  • Mr Archie Hughes-Hallett

Address:

Charing Cross Hospital
Fulham Palace Road
W6 8RF
Liverpool University Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr Robin Weston

Address:

Royal Liverpool Hospital
Outpatients 3, Urology
Mount Vernon Street
Liverpool, Merseyside
L7 8XP
Oxford University Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr Mark Sullivan

Address:

Churchill Hospital
Old Road
Headington
Oxford
OX3 7LE
East Kent Hospitals University NHS Foundation Trust

Key people:

Investigator:

  • Mr Milan Thomas

Address:

Kent and Canterbury Hospital
Ethelbert Road
Canterbury
Kent
CT1 3NG
University Hospitals of Derby and Burton NHS Foundation Trust

Key people:

Investigator:

  • Mr Rob Radcliffe

Address:

Royal Derby Hospital
Uttoxeter Road
Derby
DE22 3NE
East Sussex Healthcare NHS Trust

Key people:

Investigator:

  • Mr Karl Spiteri

Address:

Eastbourne District General Hospital
Kings Drive
Eastbourne
East Sussex
BN21 2UD
Norfolk and Norwich University Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr Mark Rochester

Address:

Norfolk and Norwich University Hospital
Colney Lane
Colney
Norwich
NR4 7UY
University Hospitals Sussex NHS Foundation Trust

Key people:

Investigator:

  • Mr Ammar Alanbuki

Address:

Princess Royal Hospital
Lewes Road
Haywards Heath
West Sussex
RH16 4EX
Wirral University Teaching Hospital NHS Foundation Trust

Key people:

Investigator:

  • Mr Thiagarajan Nambirajan

Address:

Arrowe Park Hospital
Arrowe Park Rd
Birkenhead
Wirral
CH49 5PE
Mid Yorkshire Hospitals NHS Trust

Key people:

Investigator:

  • Mr Mohammed Aldiwani

Address:

Pinderfields Hospital
Aberford Road
Wakefield
WF1 4DG
NHS Grampian

Key people:

Investigator:

  • Mr Grigorios Athanasiadis

Address:

Aberdeen Royal Infirmary
Foresterhill Health Campus
Foresterhill Rd
Aberdeen
AB25 2ZN
St George's University Hospitals NHS Foundation Trust

Key people:

Investigator:

  • Mr Christopher Anderson

Address:

St George's Hospital
Blackshaw Road
London
SW17 0QT
The Dudley Group NHS Foundation Trust

Key people:

Investigator:

  • Mr Syed Shahzad

Address:

Russells Hall Hospital
Pensnett Road
Dudley
DY1 2HQ

Study news

Recruitment

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Trial sites

Latest addition to sites:

The Dudley Group NHS Foundation Trust
St George's University Hospitals NHS Foundation Trust
NHS Grampian
Mid Yorkshire Hospitals NHS Trust

Key facts about the study and documents

What is this study about?

If you are eligible, would like to take part and your local hospital is a study site, they will send you information about the PARTIAL study.

To take part, you will be asked to complete a consent form and a questionnaire about your quality of life and your recent contact with the NHS.

After this you will be allocated at random to receive one of the treatments below:
• Surgery where the whole kidney is removed
• Surgery where part of the kidney is removed

The surgical team will arrange a date for your procedure.

Whichever surgery you receive, you will continue to receive NHS care.

We will follow you up in the study for 24 months by sending you questionnaires for you to complete at home. We will collect some information from your medical notes about the surgery and any further treatment or complications you may have had. As part of your standard NHS care you will likely have blood tests to check your kidney function and regular scans. We will also collect this information from your medical notes. We will invite you to have these blood tests done if you do not have them as part of your standard NHS care.

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Key contacts

Click on cards to find out more

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Key questions & answers

What are the possible disadvantages, risks and side effects when taking part?

We do not think that there are any possible disadvantages to taking part. If you take part in the PARTIAL study, there should be no additional risk to you. Both types of surgery are already being used in the NHS to treat patients who need kidney surgery. There are risks associated with all surgical procedures and steps are always taken to ensure that these risks are minimised. Your clinical team will advise you about all the treatment options available to you. To consider you for the study, your clinical team must confirm that you are suitable to have either operation by keyhole surgery.

What are the main risks and benefits of each type of surgery?

Some of the main risks and benefits are described below.

Surgery where the whole kidney is removed Surgery where part of the kidney is removed
• This can be an easier operation for the surgeon to do. • It can be more difficult for the surgeon to remove just part of the kidney. Sometimes during this type of operation, the surgeon has to take out the whole kidney.

• There is a lower chance of bleeding and urine leakage from the operation. • There is a higher chance of bleeding and urine leakage from the operation.
• If there is a cancer in the kidney, there is a higher chance of it all being removed. • If there is a cancer in the kidney, there is a higher chance of some cancer being left behind.
• If the whole kidney is removed, the overall kidney function may be worse because only one kidney is left to do the work of removing waste products from the body. • If part of the kidney is left in place, the overall kidney function may be better than removing the entire kidney because the part that is left behind can still help get rid of waste products from the body.
• The chance of developing kidney disease is higher. • The chance of developing kidney disease is lower.


Where can I find further information?

Kidney Cancer UK and Kidney Cancer Scotland are helping to support the PARTIAL study. The charity provides information, support and advice to people with kidney cancer, carers and their families. Find out more at https://www.kcuk.org.uk/ or by contacting their support line 0800 002 9002.
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Organisation

Funding acknowledgement

This study is funded by the NIHR Health Technology Assessment (HTA) programme (NIHR133561). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. The project is run by The Newcastle upon Tyne Hospitals NHS Foundation Trust

General Data Protection Regulation (GDPR) - Participant Information

The Newcastle upon Tyne Hospitals NHS Foundation Trust is the sponsor for this study based in the United Kingdom. We will be using information from you and your medical records in order to undertake this study and will act as the data controller for this study. This means that we are responsible for looking after your information and using it properly. The Newcastle upon Tyne Hospitals NHS Foundation Trust will keep identifiable information about you for up to 5 years after the study has finished.

Your rights to access, change or move your information are limited, as we need to manage your information in specific ways in order for the research to be reliable and accurate. If you withdraw from the study, we will keep the information about you that we have already obtained. To safeguard your rights, we will use the minimum personally-identifiable information possible.

You can find out more about how we use your information at: http://www.newcastle-hospitals.org.uk/about-us/freedom-of-information_how-we-use-information.aspx