COVID-19 update

July 2020: Recruitment to PUrE has now restarted at some centres.

March 2020: In response to COVID-19, we have paused patient recruitment into this study. We are continuing to follow-up people who are already taking part. It may be that we are in touch with you by a different method than usual (for example we may telephone you to complete questionnaires, rather than send them by post). If you have any questions about the study, please get in touch by emailing pure@abdn.ac.uk.

If you are a patient and require medical attention or advice, please contact your GP or NHS-111/NHS-24 (by dialling 111).

You can also find information about COVID-19 from the NHS websites in England, Scotland, Wales and Northern Ireland.

There is also information about COVID-19 on the UK government website.

What is PUrE?

PUrE is a research study collecting information on the different ways of treating lower pole kidney stones. PUrE stands for the Percutaneous nephrolithotomy, flexible Ureterorenoscopy and Extracorporeal shockwave lithotripsy for lower pole kidney stone.

Kidney stone disease is very common (around 10% of adults will suffer in their lifetime) and mainly affects adults of working age (18 – 55 years). Over a quarter of patients with stones will require treatment and about half of all patients will go on to develop another stone.

Although some stones do not cause any problems, patients can develop serious symptoms including pain, infection, bloody urine and their kidneys can stop working as well as normal.

The lower pole (bottom) of the kidney is the most common location for stones in the kidney. These stones are more likely to require treatment, because they can be less likely to pass on their own.

Currently within the NHS there are three treatment options for treating these stones depending on their size:

extracorporeal shockwave lithotripsy (ESWL) (find out more here: http://www.baus.org.uk/_userfiles/pages/files/Patients/Leaflets/ESWL.pdf)
percutaneous nephrolithotomy (PCNL) (find out more here: http://www.baus.org.uk/_userfiles/pages/files/Patients/Leaflets/PCNL.pdf), and
flexible ureterorenoscopy with laser lithotripsy (FURS) (find out more here: https://www.baus.org.uk/_userfiles/pages/files/Patients/Leaflets/Ureteroscopy for stone.pdf).

At the moment there is no clear evidence of what is best as reported by patients and in costs to the NHS and the aim of the PUrE study is to answer these questions. PUrE is funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme. You can find out more about taking part in research here: http://www.nihr.ac.uk/get-involved/ok-to-ask.htm

Can I take part?

You may be eligible to take part in PUrE if:

you are aged 16 or over,
with lower pole kidney stones
are being referred to hospital.
If the hospital you are referred to is taking part in PUrE, the study will be discussed further at your hospital appointment.

If you would like any more information about PUrE, including information about taking part please contact the study office at the University of Aberdeen on 01224 438156 or email pure@abdn.ac.uk.

If you are interested in taking part, or have any questions

Aberdeen Royal Infirmary

Key people:

Investigator:

Mr Ismail Mokadem

Address:

Aberdeen Royal Infirmary
Foresterhill
Aberdeen

AB25 2ZN

Norfolk and Norwich University Hospital

Key people:

Investigator:

Mr Stuart Irving

Address:

Norfolk and Norwich University Hospital
Colney Lane
Norwich

NR4 7UY

Pinderfields Hospital

Key people:

Investigator:

Mr Anthony Browning

Address:

Pinderfields Hospital
Aberford Road
Wakefield
WF1 4DG

Freeman Hospital

Key people:

Investigator:

Mr David Thomas

Address:

Freeman Hospital
Freeman Road
High Heaton
Newcastle upon Tyne
NE7 7DN

Addenbrooke’s Hospital

Key people:

Investigator:

Oliver Wiseman

Address:

Addenbrooke’s Hospital
Hills Road
Cambridge
CB2 0QQ

Royal Blackburn Hospital

Key people:

Investigator:

Mr Shalom Srirangam

Address:

Royal Blackburn Hospital
Haslingden Road
Blackburn
BB2 3HH

Southampton General Hospital

Key people:

Investigator:

Mr Bhaskar Somani

Address:

Southampton General Hospital
Tremona Road
Southampton
SO16 6YD

Southmead Hospital

Key people:

Investigator:

Mr Francis Keeley

Address:

Southmead Hospital
Dorian Way
Westbury-on-Trym
Bristol
BS10 5NB

Churchill Hospital

Key people:

Investigator:

Mr Ben Turney

Address:

Churchill Hospital
Old Road
Headington
Oxford
OX3 7LE

Charing Cross Hospital

Key people:

Investigator:

Mr Ranan Dasgupta

Address:

Charing Cross Hospital
Fulham Palace Road
London
W6 8RF

Arrowe Park Hospital

Key people:

Investigator:

Mr Snehal Patel

Address:

Arrowe Park Hospital
Arrowe Park Road
Upton, Birkenhead
Wirral
CH49 5PE

James Cook University Hospital

Key people:

Investigator:

Mr Ashok Sakthivel

Address:

James Cook University Hospital
Marton Road
Middlesbrough

TS4 3BW

Royal Hallamshire Hospital

Key people:

Investigator:

Mr Jake Patterson

Address:

Royal Hallamshire Hospital
Glossop Road
Sheffield

S10 2JF

Royal Oldham Hospital

Key people:

Investigator:

Mr Andreas Bourdomis

Address:

Royal Oldham Hospital
Rochdale Road
Manchester

OL1 2JH

Belfast City Hospital

Key people:

Investigator:

Mr David Connolly

Address:

Belfast City Hospital
Lisburn Road
Belfast

BT9 7AB

Wrexham Maelor Hospital

Key people:

Investigator:

Mr Iqbal Shergill

Address:

Croesnewydd Road
Wrexham

LL13 7TD

Derriford Hospital

Key people:

Investigator:

Mr Ivo Dukic

Address:

Derriford Hospital
Derriford Road
Plymouth

PL6 8DH

St James’s University Hospital

Key people:

Investigator:

Mr Michael Kimuli

Address:

St James’s University Hospital
Beckett Street
Leeds
LS9 7TF

Manchester Royal infirmary

Key people:

Investigator:

Mr Ben Grey

Address:

Manchester Royal Infirmary
Grafton Street
Manchester

M13 9WL

Salford Royal Hospital

Key people:

Investigator:

Mr David Ross

Address:

Stott Lane
Salford

M6 8HD

Sunderland Royal Hospital

Key people:

Investigator:

Mr David Bryant

Address:

Sunderland Royal Hospital
Kayll Road
Sunderland

SR4 7TP

Kingston Hospital

Key people:

Investigator:

Mrs Rashmi Singh

Address:

Galsworthy Road
Kingston upon Thames

KT2 7QB

Wythenshawe Hospital

Key people:

Investigator:

Mr Graham Young

Address:

Southmoor Road
Wythenshawe
Manchester

M23 9LT

Stockport NHS Foundation Trust

Key people:

Investigator:

Ms Zara Gall

Address:

Stepping Hill Hospital
Poplar Grove
Hazel Grove
Stockport
SK2 7JE

Eastbourne District General Hospital

Key people:

Investigator:

Mr Simon Mackie

Address:

King's Drive
Eastbourne
BN21 2UD

Western General Hospital

Key people:

Investigator:

Mr Mark Cutress

Address:

Department of Urology
Western General Hospital
Crewe Road South
Edinburgh
EH4 2XU

Southport & Formby District General Hospital

Key people:

Investigator:

Mr Rahul Mistry

Address:

Town Lane
Southport
Merseyside
PR8 6PN

Kent and Canterbury Hospital

Key people:

Investigator:

Ms Jemma Hale

Address:

Kent and Canterbury Hospital
Ethelbert Road
Canterbury

CT1 3NG

St Helens and Knowsley Teaching Hospitals

Key people:

Investigator:

Mr John McCabe

Address:

Whiston Hospital
Warrington Road
Rainhill
Prescot
L35 5DR

Broadgreen Hospital

Key people:

Investigator:

Mr Ciaran Lynch

Address:

Thomas Dr
Liverpool

L14 3LB

Epsom General Hospital

Key people:

Investigator:

Mr Stephen Gordon

Address:

Dorking Road
Epsom
Surrey
KT18 7EG

Dartford and Gravesham NHS Trust

Key people:

Investigator:

Mr Seshadri Sriprasad

Address:

Darent Valley Hospital
Darenth Wood Road
Dartford
Kent
DA2 8DA

Western Sussex Hospitals

Key people:

Investigator:

Mr Dan Magrill

Address:

St Richard's Hospital
Spitalfield Lane
Chichester
West Sussex
PO19 6SE

Bradford Teaching Hospitals NHS Foundation Trust

Key people:

Investigator:

Mr James Forster

Address:

Bradford Royal Infirmary
Duckworth Lane
Bradford
West Yorkshire
BD9 6RJ

Blackpool Teaching Hospitals NHS Foundation Trust

Key people:

Investigator:

Mr Jaginkere Chiran

Address:

Blackpool Victoria Hospital
Whinney Heys Road
Blackpool
Lancashire
FY3 8NR

Rotherham NHS Foundation Trust

Key people:

Investigator:

Mr Bohdan Parys

Address:

Rotherham Hospital
Moorgate Road
Rotherham
South Yorkshire
S60 2UD

Royal Sussex County Hospital

Key people:

Investigator:

Mr Andrew Symes

Address:

Royal Sussex County Hospital
Eastern Road
Brighton
East Sussex
BN2 5BE

Ashford & St. Peter's Hospitals NHS Foundation Trust

Key people:

Investigator:

Mr Sachin Agrawal

Address:

St. Peter's Hospital
Guildford Road
Chertsey
Surrey
KT16 0PZ

St. George's, University of London

Key people:

Investigator:

Mr Ken Anson

Address:

St. George's Hospital
Blackshaw Road
Tooting
London
SW17 0QT

Royal Devon & Exeter NHS Foundation Trust

Key people:

Investigator:

Miss Melanie Walton

Address:

Royal Devon & Exeter Hospital
Barrack Road
Exeter
Devon
EX2 5DW

Northwick Park Hospital

Key people:

Investigator:

Mr Erik Havranek

Address:

Northwick Park Hospital
Watford Road
Harrow
Middlesex
HA1 3UJ

Royal Berkshire NHS Foundation Trust

Key people:

Investigator:

Mr Sunil Kumar

Address:

Royal Berkshire Hospital
London Road
Reading
Berkshire
RG1 5AN

Victoria Hospital

Key people:

Investigator:

Miss Robyn Webber

Address:

Queen Margaret Hospital
Whitefield Road
Dunferml
Fife
KY12 0SU

Gloucestershire Hospitals NHS Foundation Trust

Key people:

Investigator:

Ms Kim Davenport

Address:

Gloucestershire Royal Hospital
Great Western Road
Gloucester
Gloucestershire
GL1 3NN

Royal Cornwall Hospitals NHS Trust

Key people:

Investigator:

Mr Christopher Blake

Address:

Royal Cornwall Hospitals NHS Trust
Treliske
Truro
Cornwall
TR1 3LJ

University Hospitals Coventry & Warwickshire

Key people:

Investigator:

Mr Anthony Blacker

Address:

University Hospital COventry
Clifford Bridge Road
Coventry
West Midlands
CV2 2DX

University Hospitals of Leicester NHS Trust

Key people:

Investigator:

Mr Masood Khan

Address:

Leicester General Hospital
Gwendolen Road
Leicester
East Midlands
LE5 4PW

Salisbury NHS Foundation Trust

Key people:

Investigator:

Mr James Brewin

Address:

Salisbury District Hospital
Oldstock Road
Salisbury
Wiltshire
SP2 8BJ

Key people:

Investigator:

Address:

Study news

Recruitment

625/719

Trial sites

Latest addition to sites:

                          Oops
                      
                                      Salisbury NHS Foundation Trust
                                  
                                      University Hospitals of Leicester NHS Trust
                                  
                                      University Hospitals Coventry & Warwickshire
                                  
                          Oops

Key facts about the study and documents

If you are eligible and would like to take part in the PUrE study you will be recruited at your local hospital (please see ‘Where can I take part? to check if your local hospital is participating).

To take part you will be asked to sign a consent form and asked some questions about your health. You will also be asked to complete a study questionnaire.

After this if your stone is 10mm or smaller you will be randomised to receive either ESWL (ESWL.pdf) or FURS (Ureteroscopy_stone.pdf) or if your stone is larger than 10 mm, but smaller than 25mm you will be randomised to receive either FURS (Ureteroscopy_stone.pdf) or PCNL (percutaneous_keyhole_removal_of_stones_from_kidney).

We will follow your progress for 18 months and we will send you a study questionnaire through the post at 3, 9, 12 and 18 months. We will also send you a prepaid envelope. The questionnaires are returned to the study office in a prepaid envelope.

You can find out more information about PUrE here:

Patient information leaflet for stones 10mm or less

Patient information leaflet for stones larger than 10 mm, but smaller than 25mm

Download documents:

PUrE Protocol V04 17 November 2021 (04 17 Nov 2021)

Patient Information Leaflet RCT1 (02 27Oct16)

Patient Information Leaflet RCT2 (02 27Oct16)

Key contacts

Click on cards to find out more

General Data Protection Regulation (GDPR)
Participant Information

University of Aberdeen/NHS Grampian is the sponsor for this study based in the United Kingdom. We will be using information from you and your medical records in order to undertake this study and will act as the data controller for this study. This means that we are responsible for looking after your information and using it properly. University of Aberdeen/NHS Grampian will keep identifiable information about you at least 10 years after the study has finished.

Your rights to access, change or move your information are limited, as we need to manage your information in specific ways in order for the research to be reliable and accurate. If you withdraw from the study, we will keep the information about you that we have already obtained. To safeguard your rights, we will use the minimum personally-identifiable information possible.

You can find out more about how we use your information https://www.abdn.ac.uk/privacy.

Tell us what do you think about our website?

WELCOME TO PUrE

The clinical and cost effectiveness of surgical interventions for stones in the lower pole of the kidney: The Percutaneous nephrolithotomy, flexible Ureterorenoscopy and Extracorporeal shockwave lithotripsy for lower pole kidney stones Randomised Controlled Trial (PUrE RCT)

COVID-19 update

What is PUrE?

Can I take part?

If you are interested in taking part, or have any questions

Where can I take part?

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