| Journal Ref. |
Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G: Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000, 342:145-153. |
| Intervention |
Drug - anti-hypertension drug |
| Number of sites |
282 |
| Countries involved |
USA, Mexico, Brazil, Europe etc |
| Sample size |
9297 |
| Type of statistical analyses |
|
| Risk of bias |
Overall: Low Risk
details
Random sequence generation:
-
Allocation concealment:
-
Blinding of participants, personal and outcome assessors:
-
Incomplete outcome data:
-
Selective outcome reporting:
-
Other sources of bias:
-
|
| Duration of trial |
|
| Primary outcome |
mortality |
