STOPPIT-2: An open randomised trial of the Arabin pessary to prevent preterm birth in twin pregnancy, with health economics and acceptability

This study aims to determine whether the Arabin cervical pessary prevents preterm birth in women with a twin pregnancy and a short cervix. Women with a twin pregnancy are at high risk of preterm labour.

A large randomised trial has suggested that the Arabin cervical pessary can reduce preterm birth in women with a singleton pregnancy (one baby), and many clinicians use it for this purpose. A Dutch study has suggested that the cervical pessary might also prevent preterm birth in twins. However, before all UK women with twin pregnancy and a short cervix are offered Arabin pessary treatment via the NHS, we need to be certain about the benefits and the risks of this approach.

We plan to recruit 2500 women to the SCREENING phase and randomise 500 women in the TREATMENT phase. We anticipate that around 55 sites (largely UK NHS sites) will be involved. Further written information is available including a frequently asked questions to download here

For information and advice about pessary fitting and removal, please visit Dr. Arabin GmbH & Co and watch the video here (you will need to select the UK flag to read this in English, top left hand corner of the Dr Arabin webpage). 

If you would like to information about being a particpant, please read Claire and Joanne's  experience of partcipating in STOPPIT-2 or speak to your local hospital team. A map of particpating hospitals is available with contact details on this site.

You can find information about GDPR and how we manage your data click here 

This study is being funded by the National Institute for Health Research (NIHR), Health Technology Assessment (HTA) Programme (Project: 13/04/22). The views and opinions are those of the authors and do not necessarily reflect those of the HTA programme, NIHR or the Department of Health.

You can also follow us on Twitter at @stoppit2study for study news, activties and sharing experiences.