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VUE: Vault or Uterine prolapse study Evaluation

Two parallel randomised controlled trials of surgical options for upper compartment (uterine or vault) pelvic organ prolapse

Around 1 in 10 women will need prolapse surgery at some point in their lives. Prolapse occurs when the pelvic organs (such as the bladder, the bowel or the womb) come down into, or out of, the vagina. This is caused either by weakness of the connective tissues which normally support these organs or by weak pelvic floor muscles. It is most common in women who have had children, although there has been surprisingly little research into its causes and treatment. Women can have more than one type of prolapse.

There are many different operations for prolapse: the VUE study only concerns women with a uterine (womb) or vault (top of the vagina after a woman has had a hysterectomy (womb removed) previously) prolapse. To date, there is a high failure rate after surgery: a quarter of women who have had a hysterectomy will need vault repair later. Some women may need an extra procedure if the bladder (front wall of the vagina) or bowel (back wall of the vagina) is also coming down or for leaking urine (incontinence). If necessary, the extra proceudres can be carried out at the same time.

There is not enough evidence from research to identify which operation is best for these two types of prolapse. Many operations have been tried, but these have not been properly evaluated, especially in terms of how well they improve prolapse symptoms.

The study will be carried out in around 40 hospitals in the UK. We will randomise women having surgery for uterine or vault prolapse to one of two trials:

(1) Uterine trial: vaginal hysterectomy compared with an operation to suspend the uterus without removing it, and

(2) Vault trial: suspending the vault from below (the vaginal route) copmared with suspending it via the abdomen (tummy)

This is a UK Collaborative Study funded by the NIHR HTA Programme


General Data Protection Regulation (GDPR) - Participant Information

University of Aberdeen/NHS Grampian is the sponsor for this study based in the United Kingdom. We will be using information from you and your medical records in order to undertake this study and will act as the data controller for this study. This means that we are responsible for looking after your information and using it properly. University of Aberdeen/NHS Grampian will keep identifiable information about you at least 25 years after the study has finished.


Your rights to access, change or move your information are limited, as we need to manage your information in specific ways in order for the research to be reliable and accurate. If you withdraw from the study, we will keep the information about you that we have already obtained. To safeguard your rights, we will use the minimum personally-identifiable information possible.


You can find out more about how we use your information https://www.abdn.ac.uk/about/privacy/.